8/21/20: ESPN's Nick Wagoner reported Thursday that Head Coach Kyle Shanahan is hopeful Deebo will be ready to go for the week one opener against the Arizona Cardinals. 9/7/20: Deebo didn't practice Monday, but a decision about his week one status will come in the next day or so, according to Matt Barrows of The Athletic. 9/11/20: Deebo has officially been ruled out for Sundays game against Arizona. 9/12/20: The team has placed Samuel on IR, meaning he will miss at least the next three games.
NFL Network's Ian Rapoport is reporting that Deebo will likely make his season debut in week 5.